Article
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Oncogene - 12 Jun 1997
Whitesell L, Sutphin P, An W G, Schulte T, Blagosklonny M V, Neckers L
Abstract excerpt
Mutation of the tumor suppressor gene p53 is the most common genetic abnormality detected in human cancers. Wild type p53 is a short-lived protein with very low basal intracellular levels. Most mutated forms of the protein, however, display markedly increased intracellular levels as an essential feature of their positive transforming activity. In this report, we have used selective inhibitors of the 20S...
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