Article
Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo.
Oncogene - 12 Jun 1997
Whitesell L, Sutphin P, An W G, Schulte T, Blagosklonny M V, Neckers L
Abstract excerpt
Mutation of the tumor suppressor gene p53 is the most common genetic abnormality detected in human cancers. Wild type p53 is a short-lived protein with very low basal intracellular levels. Most mutated forms of the protein, however, display markedly increased intracellular levels as an essential...
Topics
- Acetylcysteine
- Animals
- Benzoquinones
- Cycloheximide
- Cysteine Endopeptidases
- Cysteine Proteinase Inhibitors
- Detergents
- Enzyme Inhibitors
- Half-Life
- Humans
- Lactams, Macrocyclic
- Leupeptins
- Mice
- Multienzyme Complexes
- Mutation
- Octoxynol
- Polyethylene Glycols
- Proteasome Endopeptidase Complex