Article
Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds.
Nature genetics - 1 Jul 1995
Gruis N A, van der Velden P A, Sandkuijl L A, Prins D E, Weaver-Feldhaus J, Kamb A, Bergman W, Frants R R
Abstract excerpt
The p16 gene (CDKN2) which is localized on chromosome 9p21, is deleted in a significant number of sporadic cancers. Moreover, germline mutations identified in some melanoma-prone kindreds last year suggested that CDKN2 is identical to the 9p21-linked melanoma susceptibility gene (MLM); however, failure to identify p16 mutations in all melanoma kindreds putatively linked to 9p21 left some doubts. We have analysed...
Topics
- Amino Acid Sequence
- Chromosomes, Human, Pair 9
- DNA Primers
- Female
- Germ-Line Mutation
- Homozygote
- Humans
- Male
- Melanoma
- Molecular Sequence Data
- Neoplasms, Multiple Primary