CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families.

doi:10.1097/00008390-199506000-00005

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Article

CDKN2 explains part of the clinical phenotype in Dutch familial atypical multiple-mole melanoma (FAMMM) syndrome families.

Melanoma research - 1 Jun 1995

Gruis N A, Sandkuijl L A, van der Velden P A, Bergman W, Frants R R

Abstract excerpt

Combined multi-point linkage analysis in seven Dutch families with FAMMM syndrome confirmed the location of a melanoma susceptibility (MLM) gene in the 9p21 area. The occurrence of a shared high-risk haplotype in six of the families strongly suggests a founder effect in the Leiden region. No indication for locus heterogeneity was observed. Recently, the CDKN2 (p16) gene, an important regulator of the cell cycle,...

Topics

Adolescent
Adult
Aged
Amino Acid Sequence
Base Sequence
Carrier Proteins
Child
Child, Preschool
Chromosome Mapping
Cyclin-Dependent Kinase Inhibitor p16
DNA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Female

Founder Effect

Genes, Tumor Suppressor

Germ-Line Mutation

Haplotypes

Humans

Infant

Source

Open in PubMed

Identifiers

PMID: 7640518
DOI: 10.1097/00008390-199506000-00005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7640518-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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