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Article

Mutation analysis of candidate genes in melanoma-prone families: evidence of different pathogenetic mechanisms at chromosome 9P21.

Melanoma research - 1 Dec 2003

Casula Milena, Ascierto Paolo A, Cossu Antonio, Sini Maria C, Tore Silvia, Colombino Maria, Satta Maria P, Manca Antonella, Rozzo Carla, Satriano Sabrina M, Castello Giuseppe, Lissia Amelia, Tanda Francesco, Palmieri Giuseppe

Abstract excerpt

Putative tumour suppressor genes CDKN2A and CDKN2B (on chromosome 9p21) and CDKN2A-interacting cell growth regulatory genes CDK4 and Id-1 have been demonstrated to be involved in the pathogenesis of malignant melanoma (MM). Mutation analysis of these candidate genes was performed in MM families from southern Italy with three or more affected members or two affected members and one or more relative with...

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Identifiers

PMID: 14646620
DOI: 10.1097/00008390-200312000-00006

Genes

CDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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