Article
A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family.
Genes, chromosomes & cancer - 1 Dec 2006
Knappskog Stian, Geisler Jürgen, Arnesen Thomas, Lillehaug Johan R, Lønning Per E
Abstract excerpt
Linkage to the CDKN2A locus has been demonstrated in approximately 50% of families with hereditary malignant melanoma but only a subgroup of these harbor identified mutations. We here report a Norwegian melanoma-prone family with a novel large germline deletion removing 13707 bps of the CDKN2A gene, including exon 1alpha and approximately half of exon 2. Our finding is the first reported large CDKN2A germline...
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