Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas.

Oncogene - 1 Apr 1993

Leone A, Seeger R C, Hong C M, Hu Y Y, Arboleda M J, Brodeur G M, Stram D, Slamon D J, Steeg P S

Abstract excerpt

Reduced expression of nm23 RNAs/proteins has been associated previously with high tumor metastatic potential. In contrast, we report that regional (state III) and metastatic (stage IV) childhood neuroblastomas exhibit elevated nm23 RNA levels as compared with localized tumors. Elevated neuroblastoma nm23 RNA levels were associated with significant reductions in patient survival in the overall (n = 75) and N-myc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Child, Preschool

Share to DNA, Neoplasm

Share to Infant

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 8384356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas.PMID 8384356Read ↗

Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.Semantic proximity Read ↗

Increased nm23-H1 and nm23-H2 messenger RNA expression and absence of mutations in colon carcinomas of low and high metastatic potential.Semantic proximity Read ↗

High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification.Semantic proximity Read ↗

Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression.Semantic proximity Read ↗

Somatic allelic deletion of nm23 in human cancer.Semantic proximity Read ↗

Chromosome band 11q23 deletion predicts poor prognosis in bone marrow metastatic neuroblastoma patients without MYCN amplificationSemantic proximity Read ↗

NM23-H1 and NM23-H2 Repress Transcriptional Activities of Nuclease-hypersensitive Elements in the Platelet-derived Growth Factor-A PromoterSemantic proximity Read ↗

Mutation in the nm23 gene is associated with metastasis in colorectal cancer.Semantic proximity Read ↗

Expression level of the nm23 gene in clonal populations of metastatic murine and human neoplasms.Semantic proximity Read ↗

Nucleoside diphosphate kinase A/nm23-H1 promotes metastasis of NB69-derived human neuroblastoma.Semantic proximity Read ↗

Influence of neuroblastoma stage on serum‐based detection of <i>MYCN</i> amplificationSemantic proximity Read ↗

Reduced expression and rare genomic alteration of nm23-H1 in human hepatocellular carcinoma and hepatoma cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.