Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HLA class II linkage disequilibrium and haplotype evolution in the Cayapa Indians of Ecuador.

American journal of human genetics - 1 Aug 1995

Trachtenberg E A, Erlich H A, Rickards O, DeStefano G F, Klitz W

Abstract excerpt

DNA-based typing of the HLA class II loci in a sample of the Cayapa Indians of Ecuador reveals several lines of evidence that selection has operated to maintain and to diversify the existing level of polymorphism in the class II region. As has been noticed for other Native American groups, the overall level of polymorphism at the DRB1, DQA1, DQB1, and DPB1 loci is reduced relative to that found in other human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Biological Evolution
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Haplotypes

Share to Histocompatibility Antigens Class II

Share to Indians, South American

Share to Linkage Disequilibrium

Source

Open in PubMed Open full text

Identifiers

PMID: 7668268
PMCID: PMC1801536

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA class II linkage disequilibrium and haplotype evolution in the Cayapa Indians of Ecuador.PMID 7668268Read ↗

Analysis of HLA class II haplotypes in the Cayapa Indians of Ecuador: a novel DRB1 allele reveals evidence for convergent evolution and balancing selection at position 86.Semantic proximity Read ↗

HLA-DQA1 and HLA-DQB1 genes in Tsachilas Indians from Ecuador: new insights in population analysis by Human Leukocyte Antigens.Semantic proximity Read ↗

HLA class II alleles in Amerindian populations: implications for the evolution of HLA polymorphism and the colonization of the Americas.Semantic proximity Read ↗

Genetic diversity of the HLA system in human populations from the Sierra (Andean), Oriente (Amazonian) and Costa (Coastal) regions of Ecuador.Semantic proximity Read ↗

Recent origin of HLA-DRB1 alleles and implications for human evolution.Semantic proximity Read ↗

Evolution of HLA class-II polymorphism in primates: the DQA locus.Semantic proximity Read ↗

mtDNA history of the Cayapa Amerinds of Ecuador: detection of additional founding lineages for the Native American populations.Semantic proximity Read ↗

Episodic evolution and turnover of HLA-B in the indigenous human populations of the Americas.Semantic proximity Read ↗

HLA-DMB alleles and haplotypes in Ecuador (Cuenca) Amerindians: Importance for HLA and disease studies.Semantic proximity Read ↗

Evolution of the human HLA-DR regionSemantic proximity Read ↗

HLA diversity, differentiation, and haplotype evolution in Mesoamerican Natives.Semantic proximity Read ↗

Tracing the origin of HLA-DRB1 alleles by microsatellite polymorphism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.