Article
Analysis of HLA class II haplotypes in the Cayapa Indians of Ecuador: a novel DRB1 allele reveals evidence for convergent evolution and balancing selection at position 86.
American journal of human genetics - 1 Jul 1994
Titus-Trachtenberg E A, Rickards O, De Stefano G F, Erlich H A
Abstract excerpt
PCR amplification, oligonucleotide probe typing, and sequencing were used to analyze the HLA class II loci (DRB1, DQA1, DQB1, and DPB1) of an isolated South Amerindian tribe. Here we report HLA class II variation, including the identification of a new DRB1 allele, several novel DR/DQ haplotypes,...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- DNA Primers
- Ecuador
- Gene Frequency
- Genes, MHC Class II
- Genetic Variation
- HLA-DQ Antigens
- HLA-DR Antigens
- Haplotypes
- Humans
- Indians, South American
- Molecular Sequence Data
- Oligonucleotide Probes
- Point Mutation
- Polymorphism, Genetic