Article
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits.
PloS one - 1 Jan 2014
Jolivet Geneviève, Braud Sandrine, DaSilva Bruno, Passet Bruno, Harscoët Erwana, Viglietta Céline, Gautier Thomas, Lagrost Laurent, Daniel-Carlier Nathalie, Houdebine Louis-Marie, Harosh Itzik
Abstract excerpt
In the search of new strategies to fight against obesity, we targeted a gene pathway involved in energy uptake. We have thus investigated the APOB mRNA editing protein (APOBEC1) gene pathway that is involved in fat absorption in the intestine. The APOB gene encodes two proteins, APOB100 and APOB48, via the editing of a single nucleotide in the APOB mRNA by the APOBEC1 enzyme. The APOB48 protein is mandatory for...
Topics
- APOBEC-1 Deaminase
- Animals
- Animals, Genetically Modified
- Apolipoprotein B-48
- Base Sequence
- Cholesterol
- Cytidine Deaminase
- Diet, High-Fat
- Gene Expression
- Gene Knockdown Techniques
- Humans
- Intestinal Mucosa
- Liver