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Article

Elimination of apolipoprotein B48 formation in rat hepatoma cell lines transfected with mutant human apolipoprotein B cDNA constructs.

The Journal of biological chemistry - 15 Jan 1992

Yao Z M, Blackhart B D, Johnson D F, Taylor S M, Haubold K W, McCarthy B J

Abstract excerpt

Rat hepatoma McA-RH7777 cell lines transfected with full-length human apolipoprotein (apo) B constructs produce mostly human apoB48 and only small amounts of apoB100, as a result of mRNA editing at codon 2153 (C to U conversion at nucleotide 6666). To abolish the formation of apoB48 and increase the yield of apoB100 and other forms of apoB longer than apoB48, site-specific mutations were introduced at or near the...

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PMID: 1730641

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