Insertion of primary syncytium-inducing (SI) and non-SI envelope V3 loops in human immunodeficiency virus type 1 (HIV-1) LAI reduces neutralization sensitivity to autologous, but not heterologous, HIV-1 antibodies.

doi:10.1128/JVI.69.10.6342-6351.1995

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Article

Insertion of primary syncytium-inducing (SI) and non-SI envelope V3 loops in human immunodeficiency virus type 1 (HIV-1) LAI reduces neutralization sensitivity to autologous, but not heterologous, HIV-1 antibodies.

Journal of virology - 1 Oct 1995

Hogervorst E, de Jong J, van Wijk A, Bakker M, Valk M, Nara P, Goudsmit J

Abstract excerpt

The aim of the study was to investigate the influence of V3 loops from naturally occurring viruses on the neutralization sensitivity of a molecularly cloned virus. A selection of well-defined syncytium-inducing (SI) and non-SI V3 loops of a single human immunodeficiency virus type 1-infected individual (H594) and the V3 regions of two SI laboratory strains were inserted in an infectious molecular clone of human...

Topics

Acquired Immunodeficiency Syndrome
Amino Acid Sequence
Cloning, Molecular
Consensus Sequence
Gene Products, env
Giant Cells
HIV Antibodies
HIV Antigens
HIV-1
Homosexuality, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immunoglobulin G

Male

Molecular Sequence Data

Mutagenesis, Insertional

Neutralization Tests

Phenotype

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 7666535
DOI: 10.1128/JVI.69.10.6342-6351.1995
PMCID: PMC189533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7666535-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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