Article
Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Sept 1995
Silos-Santiago I, Molliver D C, Ozaki S, Smeyne R J, Fagan A M, Barbacid M, Snider W D
Abstract excerpt
Experiments over the past decade in which NGF/TrkA signaling has been abolished by antibodies or targeted gene mutations have shown that 70-85% of dorsal root ganglion (DRG) neurons require NGF for survival during development. There is consensus that many of the NGF-dependent neurons are small-diameter, peptidergic neurons subserving nociception. These neurons express the signaling receptor for NGF, TrkA. There...
Topics
- Animals
- Axons
- Cell Survival
- Ganglia, Spinal
- Heterozygote
- Homozygote
- Lectins
- Mice
- Mice, Knockout
- Mutation
- Neurofilament Proteins