Article
Characterization of p53 gene mutations in basal-cell carcinomas: comparison between sun-exposed and less-exposed skin areas.
International journal of cancer - 15 Mar 1996
Matsumura Y, Nishigori C, Yagi T, Imamura S, Takebe H
Abstract excerpt
Mutations in the p53 gene in 32 basal-cell carcinomas (BCC) developed in Japanese patients were identified by the polymerase chain reaction and single-strand-conformation polymorphism analysis, followed by sequencing the DNA. Among 16 BCC developed in continuously sun-exposed areas, 6 tumors showed 7 base substitutions, most of which were G:C to A:T transitions, mainly at the dipyrimidine sites. Seven out of 16...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
