Article
Regulation of cellular response to cisplatin-induced DNA damage and DNA repair in cells overexpressing p185(erbB-2) is dependent on the ras signaling pathway.
Oncogene - 17 Apr 1997
Yen L, Nie Z R, You X L, Richard S, Langton-Webster B C, Alaoui-Jamali M A
Abstract excerpt
We have examined the role of erbB-2 expression in the modulation of cellular toxicity to cisplatin. We have demonstrated that treatment of NIH3T3-erbB-2 cells, which overexpress the p185(erbB-2) product of the human erbB-2 gene, with a monoclonal antibody directed against the extracellular domain...
Topics
- 3T3 Cells
- Animals
- Antibodies, Monoclonal
- Antibody Specificity
- Antineoplastic Agents
- Benzoquinones
- Cell Cycle
- Cisplatin
- DNA Damage
- DNA Repair
- Down-Regulation
- Enzyme Inhibitors
- Humans
- Lactams, Macrocyclic
- Mice
- Mice, Inbred BALB C
- Mutation
- Protein-Tyrosine Kinases