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Article

Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk.

Cancer research - 15 Sept 1995

Reichardt J K, Makridakis N, Henderson B E, Yu M C, Pike M C, Ross R K

Abstract excerpt

Elevated dihydrotestosterone levels have been suggested to increase the risk of prostate cancer. The human SRD5A2 gene encodes the type II steroid 5 alpha-reductase, which converts testosterone to the more bioactive compound dihydrotestosterone. We have determined the distribution of a dinucleotide repeat in low-risk Asian-Americans, high-risk African-Americans, and intermediate-risk non-Hispanic Whites. We found...

Topics

3-Oxo-5-alpha-Steroid 4-Dehydrogenase
Aged
Alleles
Asian People
Base Sequence
Black People
Female
Genetic Variation
Genotype
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Prostatic Neoplasms

Risk

White People

Black or African American

Source

Identifiers

PMID: 7664265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7664265-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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