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Article

Genetic variation of 3 beta-hydroxysteroid dehydrogenase type II in three racial/ethnic groups: implications for prostate cancer risk.

The Prostate - 15 Sept 1997

Devgan S A, Henderson B E, Yu M C, Shi C Y, Pike M C, Ross R K, Reichardt J K

Abstract excerpt

BACKGROUND: Elevated prostatic dihydrotestosterone (DHT) has been suggested to increase the risk of prostate cancer. The HSD3B2 gene encodes the type II 3 beta-hydroxysteroid dehydrogenase: one of two enzymes that initiate the inactivation of DHT. Thus, the HSD3B2 gene is a candidate gene for predisposition to prostate cancer. METHODS: We have determine the distribution of a complex dinucleotide repeat in the...

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Identifiers

PMID: 9294620
DOI: 10.1002/(sici)1097-0045(19970915)33:1<9::aid-pros2>3.0.co;2-h

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