Article
Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility.
European urology - 1 Jan 1999
Ross R K, Coetzee G A, Pearce C L, Reichardt J K, Bretsky P, Kolonel L N, Henderson B E, Lander E, Altshuler D, Daley G
Abstract excerpt
The prostate is an androgen-regulated organ, which has led to longstanding interest in the role of androgens in prostate carcinogenesis. Although evidence of a hormonal etiology for prostate cancer is strong, it is almost entirely circumstantial. Much of the problem in proving a causal relationship relates to the continued difficulties in reliably measuring human tissue-specific exposure to endogenous steroid...
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