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Article

Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate cancer progression.

The Journal of urology - 1 Apr 1999

Akalu A, Dlmajian D A, Highshaw R A, Nichols P W, Reichardt J K

Abstract excerpt

Prostate cancer is a serious public health problem in many industrialized countries. Androgens appear to play a critical role in its etiology. Specifically, the active androgen in the prostate, dihydrotestosterone (DHT) which is synthesized by the enzyme steroid 5alpha-reductase from testosterone (T), acts as a mitogen. Hence androgen-deprivation is commonly used during prostate cancer therapy. Two isozymes for...

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PMID: 10081907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate cancer progression.PMID 10081907Read ↗

Identification and characterization of somatic steroid 5alpha-reductase (SRD5A2) mutations in human prostate cancer tissue.Semantic proximity Read ↗

Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk.Semantic proximity Read ↗

Evidence for an association between the SRD5A2 (type II steroid 5 alpha-reductase) locus and prostate cancer in Italian patients.Semantic proximity Read ↗

SRD5A2 gene polymorphisms and the risk of benign prostatic hyperplasia but not prostate cancer.Semantic proximity Read ↗

Pharmacogenetics of human androgens and prostatic diseases.Semantic proximity Read ↗

TA repeat polymorphism of the 5alpha-reductase gene and breast cancer.Semantic proximity Read ↗

Longer (TA)n repeat but not A49T and V89L polymorphisms in SRD5A2 gene may confer prostate cancer risk in South Indian men.Semantic proximity Read ↗

A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.Semantic proximity Read ↗

Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer.Semantic proximity Read ↗

Association between two polymorphisms in the SRD5A2 gene and serum androgen concentrations in British men.Semantic proximity Read ↗

Association of prostate cancer risk and aggressiveness to androgen pathway genes: SRD5A2, CYP17, and the AR.Semantic proximity Read ↗

Polymorphic markers in the SRD5A2 gene and prostate cancer risk: a population-based case-control study.Semantic proximity Read ↗

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