Article
Somatic mutations at the SRD5A2 locus encoding prostatic steroid 5alpha-reductase during prostate cancer progression.
The Journal of urology - 1 Apr 1999
Akalu A, Dlmajian D A, Highshaw R A, Nichols P W, Reichardt J K
Abstract excerpt
Prostate cancer is a serious public health problem in many industrialized countries. Androgens appear to play a critical role in its etiology. Specifically, the active androgen in the prostate, dihydrotestosterone (DHT) which is synthesized by the enzyme steroid 5alpha-reductase from testosterone (T), acts as a mitogen. Hence androgen-deprivation is commonly used during prostate cancer therapy. Two isozymes for...
Topics
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
- Aged
- Dinucleotide Repeats
- Disease Progression
- Humans
- Male
- Middle Aged
- Mutation
- Prostatic Neoplasms