Article
No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned.
Human molecular genetics - 15 Aug 2008
Pearce C Leigh, Van Den Berg David J, Makridakis Nick, Reichardt Juergen K V, Ross Ronald K, Pike Malcolm C, Kolonel Laurence N, Henderson Brian E
Abstract excerpt
The steroid 5-alpha reductase type II gene (SRD5A2) encodes the enzyme which converts testosterone (T) to the more active androgen dihydrotestosterone. A non-synonymous single-nucleotide polymorphism, A49T (rs9282858), in SRD5A2 has been implicated in prostate cancer risk; however, results have been inconsistent. In 1999, we reported a strong association between the A49T variant and prostate cancer risk among...
Topics
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
- Aged
- California
- Case-Control Studies
- Cohort Studies
- Genetic Predisposition to Disease
- Genotype
- Hawaii
- Humans
- Male
- Middle Aged