Article
Enhanced PCR amplification of VNTR locus D1S80 using peptide nucleic acid (PNA).
Nucleic acids research - 11 Aug 1995
Demers D B, Curry E T, Egholm M, Sozer A C
Abstract excerpt
Use of the polymerase chain reaction (PCR) to amplify variable numbers of tandem repeat (VNTR) loci has become widely used in genetic typing. Unfortunately, preferential amplification of small allelic products relative to large allelic products may result in incorrect or ambiguous typing in a heterozygous sample. The mechanism for preferential amplification has not been elucidated. Recently, PNA oligomers...
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