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Article

Modified oligonucleotides as tools for allele-specific amplification.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007

Strerath Michael, Detmer Ilka, Gaster Jens, Marx Andreas

Abstract excerpt

Allele-specific polymerase chain reaction (PCR), a method that reports nucleotide variations through either the presence or the absence of a DNA product obtained through PCR amplification, holds the promise to combine target amplification and analysis in one single step. Recently, it has been reported that the selectivity of allele-specific PCR can be significantly increased through the employment of chemically...

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PMID: 17951803
DOI: 10.1007/978-1-59745-528-2_16

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