Article
Increasing binding of a transcription factor immediately downstream of the cap site of a cytomegalovirus gene represses expression.
Nucleic acids research - 11 Aug 1995
Zhang X Y, Ni Y S, Saifudeen Z, Asiedu C K, Supakar P C, Ehrlich M
Abstract excerpt
A closely related family of ubiquitous DNA binding proteins, called MDBP, binds with high affinity to two 14 base pair (bp) sites within the human cytomegalovirus immediate early gene 1 (CMV IE1) enhancer and with low affinity to one site beginning 5 bp downstream of the CMV IE1 transcription start point (+5 site). Unlike several cap position downstream MDBP sites in mammalian genes, these MDBP sites do not...
Topics
- Base Sequence
- Binding Sites
- Cell Line
- Cyclic AMP Response Element-Binding Protein
- Cytomegalovirus
- DNA, Viral
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Gene Expression Regulation, Viral
- Genes, Immediate-Early