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Article

Large-mutation spectra induced at hemizygous loci by low-LET radiation: evidence for intrachromosomal proximity effects.

Radiation research - 1 Nov 2001

Costes S, Sachs R, Hlatky L, Vannais D, Waldren C, Fouladi B

Abstract excerpt

A mathematical model is used to analyze mutant spectra for large mutations induced by low-LET radiation. The model equations are based mainly on two-break misrejoining that leads to deletions or translocations. It is assumed, as a working hypothesis, that the initial damage induced by low-LET radiation is located randomly in the genome. Specifically, we analyzed data for two hemizygous loci: CD59- mutants, mainly...

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PMID: 11604068
DOI: 10.1667/0033-7587(2001)156[0545:lmsiah]2.0.co;2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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