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Article

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway.

Nature - 24 Aug 1995

Simon M N, De Virgilio C, Souza B, Pringle J R, Abo A, Reed S I

Abstract excerpt

In the budding yeast Saccharomyces cerevisiae, the process of conjugation of haploid cells of genotype MATa and MAT alpha to form MATa/alpha diploids is triggered by pheromones produced by each mating type. These pheromones stimulate a cellular response by interaction with receptors linked to a heterotrimeric G protein. Although genetic analysis indicates that the pheromone signal is transmitted through the G...

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Source

Identifiers

PMID: 7651520
DOI: 10.1038/376702a0

Genes

CDC42

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway.PMID 7651520Read ↗

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Cdc42p GDP/GTP cycling is necessary for efficient cell fusion during yeast mating.Semantic proximity Read ↗

The role of Cdc42 in signal transduction and mating of the budding yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.Semantic proximity Read ↗

Pheromone signaling mechanisms in yeast: a prototypical sex machine.Semantic proximity Read ↗

Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

GTPase-activating proteins for Cdc42.Semantic proximity Read ↗

The exchange factor Cdc24 is required for cell fusion during yeast mating.Semantic proximity Read ↗

Gbetagamma recruits Rho1 to the site of polarized growth during mating in budding yeast.Semantic proximity Read ↗

Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p.Semantic proximity Read ↗

Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.Semantic proximity Read ↗

Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity.Semantic proximity Read ↗

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