Article
Apoptotic phenotype induced by overexpression of wild-type gas3/PMP22: its relation to the demyelinating peripheral neuropathy CMT1A.
Genes & development - 1 Aug 1995
Fabbretti E, Edomi P, Brancolini C, Schneider C
Abstract excerpt
Although the Gas3/PMP22 protein is expressed at highest levels in differentiated Schwann cells, its presence, albeit at lower levels, in non-neuronal tissues and in NIH-3T3 growth-arrested fibroblasts argues for a more general function of this protein that is uncoupled to myelin structure. We sho...
Topics
- 3T3 Cells
- Animals
- Apoptosis
- Base Sequence
- Blotting, Western
- Cell Nucleus
- Charcot-Marie-Tooth Disease
- Demyelinating Diseases
- Escherichia coli
- Fluorescent Antibody Technique
- Humans
- Mice
- Microinjections
- Microscopy, Confocal
- Molecular Sequence Data
- Myelin Proteins
- Peripheral Nervous System
- Phenotype