Article
Human recombinant IL-4 decreases the emergence of non-specific cytolytic cells and favours the appearance of memory cells (CD4+CD45RO+) in the IL-2-driven development of cytotoxic T lymphocytes against autologous ovarian tumour cells.
Clinical and experimental immunology - 1 Aug 1995
Roth A D, Dupuis S, Alberto P
Abstract excerpt
As IL-4 and IL-6 have also been reported to promote the development of T lymphocytes such as IL-2, we investigated their role in the development of specific cytotoxic T lymphocytes (CTL) against autologous ovarian tumours in mixed lymphocyte tumour cultures (MLTC). Peripheral blood lymphocytes (P...
Topics
- CD4 Antigens
- Cells, Cultured
- Down-Regulation
- Female
- Humans
- Immunologic Memory
- Interleukin-2
- Interleukin-4
- Interleukin-6
- Killer Cells, Lymphokine-Activated
- Killer Cells, Natural
- Leukocyte Common Antigens
- Lymphocyte Activation
- Lymphocyte Culture Test, Mixed