Article
An aberrant splicing using a 3' cryptic splice site within the CH1 exon induces truncated mu-chain production.
Immunology - 1 May 1995
Komori T, Sugiyama H
Abstract excerpt
AT8--1-12--5-1, an Abelson virus-transformed immature B-cell line, produced truncated mu-chains. Sequencing analysis of the mu-expressed allele revealed that the variable region was an out-of-frame VH7183-DSP2-JH3 complex. Two cDNA clones (5-1 cDNA1 and 5-1 cDNA2) derived from the transcripts of the mu-expressed allele were cloned and sequenced. Sequencing analysis of 5-1 cDNA1 revealed that the VH7183-DSP2-JH3...
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