An aberrant splicing using a 3' cryptic splice site within the CH1 exon induces truncated mu-chain production.

Article

An aberrant splicing using a 3' cryptic splice site within the CH1 exon induces truncated mu-chain production.

Immunology - 1 May 1995

Komori T, Sugiyama H

Abstract excerpt

AT8--1-12--5-1, an Abelson virus-transformed immature B-cell line, produced truncated mu-chains. Sequencing analysis of the mu-expressed allele revealed that the variable region was an out-of-frame VH7183-DSP2-JH3 complex. Two cDNA clones (5-1 cDNA1 and 5-1 cDNA2) derived from the transcripts of...

Topics

Alleles
Animals
Base Sequence
Blotting, Northern
Blotting, Southern
Cell Transformation, Viral
DNA, Complementary
Exons
Immunoglobulin mu-Chains
Mice
Mice, Inbred BALB C
Molecular Sequence Data
RNA Splicing

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