Article
Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development.
Development (Cambridge, England) - 1 Jul 1995
Rushton E, Drysdale R, Abmayr S M, Michelson A M, Bate M
Abstract excerpt
We have used mutations in the newly identified gene myoblast city to investigate the founder cell hypothesis of muscle development in Drosophila melanogaster. In embryos mutant for myoblast city the fusion of myoblasts into multinucleate muscles is virtually abolished. Nevertheless, a subset of the myoblasts develop specific muscle-like characteristics, including gene expression appropriate to particular muscles,...
Topics
- Animals
- Drosophila
- Gene Expression
- Genes, Insect
- Genes, Lethal
- Immunohistochemistry
- Models, Biological
- Morphogenesis
- Muscles
- Mutation
- Stem Cells