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Article

Drosophila dumbfounded: a myoblast attractant essential for fusion.

Cell - 21 Jul 2000

Ruiz-Gómez M, Coutts N, Price A, Taylor M V, Bate M

Abstract excerpt

Aggregation and fusion of myoblasts to form myotubes is essential for myogenesis in many organisms. In Drosophila the formation of syncytial myotubes is seeded by founder myoblasts. Founders fuse with clusters of fusion-competent myoblasts. Here we identify the gene dumbfounded (duf) and show that it is required for myoblast aggregation and fusion. duf encodes a member of the immunoglobulin superfamily of...

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Source

Identifiers

PMID: 10943839
DOI: 10.1016/s0092-8674(00)00024-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Drosophila dumbfounded: a myoblast attractant essential for fusion.PMID 10943839Read ↗

Drosophila rolling pebbles: a multidomain protein required for myoblast fusion that recruits D-Titin in response to the myoblast attractant Dumbfounded.Semantic proximity Read ↗

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kette and blown fuse interact genetically during the second fusion step of myogenesis in Drosophila.Semantic proximity Read ↗

Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion.Semantic proximity Read ↗

The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo.Semantic proximity Read ↗

Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion.Semantic proximity Read ↗

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