Article
rst and its paralogue kirre act redundantly during embryonic muscle development in Drosophila.
Development (Cambridge, England) - 1 Nov 2001
Strünkelnberg M, Bonengel B, Moda L M, Hertenstein A, de Couet H G, Ramos R G, Fischbach K F
Abstract excerpt
The polynucleate myotubes of vertebrates and invertebrates form by fusion of myoblasts. We report the involvement of the Drosophila melanogaster Roughest (Rst) protein as a new membrane-spanning component in this process. Rst is strongly expressed in mesodermal tissues during embryogenesis, but rst null mutants display only subtle embryonic phenotypes. Evidence is presented that this is due to functional...
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