No evidence that common allelic variation in the Amyloid Precursor Protein (APP) gene confers susceptibility to Alzheimer's disease.

doi:10.1093/hmg/4.5.853

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Article

No evidence that common allelic variation in the Amyloid Precursor Protein (APP) gene confers susceptibility to Alzheimer's disease.

Human molecular genetics - 1 May 1995

Liddell M B, Bayer A J, Owen M J

Abstract excerpt

In order to test the hypothesis that allelic variation within the Amyloid Precursor Protein (APP) gene influences susceptibility to common forms of Alzheimer's disease (AD) we screened the entire coding, promoter and 3' untranslated sequences of the APP gene for DNA variations in 30 unrelated patients and eight controls with probable AD by a combination of RT-PCR PCR and chemical cleavage mismatch analysis....

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Amyloid
DNA
Exons
Female
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Point Mutation

Polymerase Chain Reaction

Prion Proteins

Prions

Source

Open in PubMed

Identifiers

PMID: 7633445
DOI: 10.1093/hmg/4.5.853

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7633445-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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