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Mutational screening of APP gene in patients with early-onset Alzheimer disease utilizing mismatched PCR-RFLP.

Clinical genetics - 1 Mar 1996

Nishiwaki Y, Kamino K, Yoshiiwa A, Nagano K, Takeda M, Tanabe H, Nishimura T, Kobayashi T, Yamamoto H, Nonomura Y, Yoneda H, Sakai T, Imagawa M, Miki T, Ogihara T

Abstract excerpt

To elucidate the frequency of mutations of the beta/A4 amyloid protein precursor (APP) gene in early-onset Alzheimer disease, we designed a mismatched PCR-RFLP that can identify all kinds of missense mutations at codon 717 in addition to the seven kinds of known mutations at exon 17. When we screened mutations at exon 17 utilizing this method and the double missense mutations at exon 16 of the APP gene by...

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Source

Identifiers

PMID: 8737975
DOI: 10.1111/j.1399-0004.1996.tb03269.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Mutational screening of APP gene in patients with early-onset Alzheimer disease utilizing mismatched PCR-RFLP.PMID 8737975Read ↗

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Screening for the beta-amyloid precursor protein mutation (APP717: Val----Ile) in extended pedigrees with early onset Alzheimer's disease.Semantic proximity Read ↗

The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.Semantic proximity Read ↗

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