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Article

Important roles of hydroxylic amino acid residues in the function of Bacillus subtilis adenylosuccinate lyase.

Protein science : a publication of the Protein Society - 1 Mar 2007

Segall Mark L, Cashman Meghan A, Colman Roberta F

Abstract excerpt

Thr(93), Ser(94), Thr(140), and Ser(306) are conserved in all adenylosuccinate lyases (ASL) and are close to other amino acids previously identified by mutagenesis as being in the active site. To test their involvement in the enzyme's function, each of these amino acids was replaced by alanine. All the mutants exhibit circular dichroism spectra which are similar to that of wild-type enzyme, indicating there is no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17322529
DOI: 10.1110/ps.062650007
PMCID: PMC2203318

Genes

ASL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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