Article
A molecular mechanism for stress-induced alterations in susceptibility to disease.
Lancet (London, England) - 8 Jul 1995
Licinio J, Gold P W, Wong M L
Abstract excerpt
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide which mediates behavioural and physiological responses to stress. A major target of CRH is the proopiomelanocortin (POMC) gene. Three transcription factors have been identified that affect transcription of the POMC gene by binding t...
Topics
- Base Sequence
- Breast Neoplasms
- Corticotropin-Releasing Hormone
- Cytomegalovirus
- Genetic Predisposition to Disease
- Genome, Viral
- HIV-1
- Humans
- Inflammation Mediators
- Molecular Sequence Data
- Oncogenes
- Pro-Opiomelanocortin
- Promoter Regions, Genetic
- Protein-Tyrosine Kinases
- Proto-Oncogenes
- Sequence Homology, Nucleic Acid
- Stress, Physiological
- Transcription Factors