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Article

A molecular mechanism for stress-induced alterations in susceptibility to disease.

Lancet (London, England) - 8 Jul 1995

Licinio J, Gold P W, Wong M L

Abstract excerpt

Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide which mediates behavioural and physiological responses to stress. A major target of CRH is the proopiomelanocortin (POMC) gene. Three transcription factors have been identified that affect transcription of the POMC gene by binding to two different sites within the CRH-responsive element of that promoter. We searched Genbank and found that nucleotide...

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Source

Identifiers

PMID: 7626147
DOI: 10.1016/s0140-6736(95)92119-2

Genes

CRH
POMC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A molecular mechanism for stress-induced alterations in susceptibility to disease.PMID 7626147Read ↗

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60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expressionSemantic proximity Read ↗

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