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Article

Two Distinctive POMC Promoters Modify Gene Expression in Cushing Disease

1 Jun 2021

Abstract excerpt

CONTEXT: Mechanisms underlying pituitary corticotroph adenoma adrenocorticotropin (ACTH) production are poorly understood, yet circulating ACTH levels closely correlate with adenoma phenotype and clinical outcomes. OBJECTIVE: We characterized the 5' ends of proopiomelanocortin (POMC) gene transcripts, which encode the precursor polypeptide for ACTH, in order to investigate additional regulatory mechanisms of POMC...

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PMID: 34061962
DOI: 10.1210/clinem/dgab387

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