Proopiomelanocortin gene expression and DNA methylation: implications for Cushing's syndrome and beyond

doi:10.1677/joe.0.1770365

Article

Proopiomelanocortin gene expression and DNA methylation: implications for Cushing's syndrome and beyond

1 Jun 2003

Abstract excerpt

Proopiomelanocortin gene (POMC) is recognised as playing an important role in the regulation of the hypothalamo-pituitary-adrenal axis, adrenal development and obesity. POMC is activated in ACTH-dependent Cushing's syndrome. The syndrome may occur when the highly tIssue-specific 5' promoter of human POMC is activated in pituitary and non-pituitary sites. Whilst the factors involved in transcription in the...

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