Article
Interleukin 12 suppresses autoantibody production by reversing helper T-cell phenotype in hepatitis B e antigen transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995
Milich D R, Wolf S F, Hughes J L, Jones J E
Abstract excerpt
Helper T (Th) cells are classified as Th1 or Th2 cells by virtue of cytokine secretion and function as mediators of cellular or humoral immunity, respectively. Cytokines also regulate the differentiation of Th cells. For example, interleukin (IL)-12 promotes Th1 and suppresses Th2 cell developmen...
Topics
- Animals
- Antibodies, Viral
- Autoantibodies
- Autoimmune Diseases
- Cells, Cultured
- Cytokines
- Hepatitis B e Antigens
- Immunoglobulin G
- Immunoglobulin Isotypes
- Immunosuppression Therapy
- Immunotherapy, Adoptive
- Interleukin-12
- Mice
- Mice, Transgenic
- Phenotype
- Recombinant Proteins
- T-Lymphocytes, Helper-Inducer
- Th1 Cells