Article
Apolipoprotein E4 allele frequency in Spanish Alzheimer and control cases.
Neuroscience letters - 21 Apr 1995
Adroer R, Santacruz P, Blesa R, López-Pousa S, Ascaso C, Oliva R
Abstract excerpt
We have found an APOE epsilon 4 allelic frequency of 0.289 (95% CI 0.195-0.383) in Spanish AD patients (n = 88; average age = 71.2 +/- 9.37) and of 0.061 (95% CI 0.023-0.099) in age-matched controls (n = 147; average age = 71.5 +/- 10.29). Remarkably no ApoE 4/4 subjects were observed in any of the age-matched control groups compared to a total of 22 AD patients with the ApoE 4/4 phenotype. The combined odds...
Topics
- Adult
- Age of Onset
- Aged
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Female
- Genotype
- Heterozygote
- Humans
- Male