Article
Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1998
Krempler F, Hell E, Winkler C, Breban D, Patsch W
Abstract excerpt
Obesity is associated with insulin resistance and other major cardiovascular risk factors. A common amino acid polymorphism at codon 972 of the insulin receptor substrate-1 (IRS-1) has been shown to interact with obesity in the expression of insulin resistance. The plasma concentration of the adi...
Topics
- Adult
- Amino Acid Substitution
- Arginine
- Blood Glucose
- Case-Control Studies
- Codon
- Female
- Genotype
- Glycine
- Humans
- Insulin Receptor Substrate Proteins
- Insulin Resistance
- Leptin
- Male
- Middle Aged
- Obesity
- Phosphoproteins
- Polymorphism, Genetic