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Article

Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 1998

Krempler F, Hell E, Winkler C, Breban D, Patsch W

Abstract excerpt

Obesity is associated with insulin resistance and other major cardiovascular risk factors. A common amino acid polymorphism at codon 972 of the insulin receptor substrate-1 (IRS-1) has been shown to interact with obesity in the expression of insulin resistance. The plasma concentration of the adipocyte-specific hormone leptin is increased in obesity and is correlated with adipose tissue mass. Because in vitro...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9812905
DOI: 10.1161/01.atv.18.11.1686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Plasma leptin levels: interaction of obesity with a common variant of insulin receptor substrate-1.PMID 9812905Read ↗

Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.Semantic proximity Read ↗

The G972R variant of the insulin receptor substrate-1 (IRS-1) gene, body fat distribution and insulin-resistance.Semantic proximity Read ↗

Metabolic risk markers in an overweight and normal weight population with oversampling of carriers of the IRS-1 972Arg-variant.Semantic proximity Read ↗

A study on the genetics of obesity: influence of polymorphisms of the beta-3-adrenergic receptor and insulin receptor substrate 1 in relation to weight loss, waist to hip ratio and frequencies of common cardiovascular risk factors.Semantic proximity Read ↗

The Arg972 variant in insulin receptor substrate-1 is associated with an atherogenic profile in offspring of type 2 diabetic patients.Semantic proximity Read ↗

A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease.Semantic proximity Read ↗

A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls.Semantic proximity Read ↗

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Very high frequency of the polymorphism for the insulin receptor substrate 1 (IRS-1) at codon 972 (glycine972arginine) in Southern Italian women with polycystic ovary syndrome.Semantic proximity Read ↗

Role of allelic variants Gly972Arg of IRS-1 and Gly1057Asp of IRS-2 in moderate-to-severe insulin resistance of women with polycystic ovary syndrome.Semantic proximity Read ↗

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Polymorphisms in the insulin receptor substrate-1 (IRS-1) gene and the insulin receptor substrate-2 (IRS-2) gene influence glucose homeostasis and body mass index in women with polycystic ovary syndrome and non-hyperandrogenic controlsSemantic proximity Read ↗

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