Article
Effect of increased glucocorticoid responsiveness in transformed mouse lung cells.
Molecular carcinogenesis - 1 Jul 1995
Li J, Beer D G
Abstract excerpt
Many transformed mouse lung cells, including LM2 cells, contain activating mutations in the Ki-ras gene and show reduced responsiveness to growth inhibition by glucocorticoids. LM2GR cells, which are LM2 cells stably transfected with a rat glucocorticoid receptor (GR) gene, were used to determine whether increasing glucocorticoid responsiveness can influence aspects of the transformed phenotype. LM2GR cells grew...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- DNA, Recombinant
- Dexamethasone
- Gene Expression
- Genes
- Genes, fos
- Genes, jun
- Genes, ras
- Histones