Article
Suppression of cellular transformation by glucocorticoid receptor mutants.
Cancer research - 1 Mar 1998
Kameda T, Iba H
Abstract excerpt
Glucocorticoid receptor (GR) has been shown to suppress activator protein 1 (AP-1)-mediated transcription by several molecular mechanisms. We previously showed that activation of endogenous AP-1 is essential for cellular transformation induced by oncogenes, such as v-src and c-Ha-ras. In the pres...
Topics
- Animals
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Chick Embryo
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Genes, src
- Genetic Vectors
- Mutation
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Receptors, Glucocorticoid
- Retroviridae
- Transcription Factor AP-1
- Transcription, Genetic