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Article

Suppression of cellular transformation by glucocorticoid receptor mutants.

Cancer research - 1 Mar 1998

Kameda T, Iba H

Abstract excerpt

Glucocorticoid receptor (GR) has been shown to suppress activator protein 1 (AP-1)-mediated transcription by several molecular mechanisms. We previously showed that activation of endogenous AP-1 is essential for cellular transformation induced by oncogenes, such as v-src and c-Ha-ras. In the present study, we have analyzed whether high levels of GR expression suppress cellular transformation caused by these...

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PMID: 9500440

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