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Article

RNA polymerase (rpoB) mutants selected for increased resistance to gyrase inhibitors in Salmonella typhimurium.

Molecular & general genetics : MGG - 25 Jun 1995

Blanc-Potard A B, Gari E, Spirito F, Figueroa-Bossi N, Bossi L

Abstract excerpt

Some rifampicin-resistance (RifR) mutations make bacteria slightly resistant to the gyrase inhibitors novobiocin (Nov) and nalidixic acid (Nal). This suggested that it might be possible to isolate rpoB mutants using either drug for positive selection. In an initial test, we confirmed the presence...

Topics

DNA Gyrase
DNA Replication
DNA Topoisomerases, Type II
DNA-Directed RNA Polymerases
Drug Resistance, Microbial
Histidine
Kinetics
Lac Operon
Mutation
Nalidixic Acid
Novobiocin
RNA, Transfer, His

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rifampin

Salmonella typhimurium

Topoisomerase II Inhibitors

Transcription, Genetic

Source

Identifiers

PMID: 7616959
DOI: 10.1007/BF00290399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7616959-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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RNA polymerase (rpoB) mutants selected for increased resistance to gyrase inhibitors in Salmonella typhimurium.PMID 7616959Read ↗

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