Article
Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months.
Carcinogenesis - 1 Jul 1995
Sills R C, Hong H L, Greenwell A, Herbert R A, Boorman G A, Devereux T R
Abstract excerpt
The National Toxicology Program recently completed long-term ozone inhalation studies in B6C3F1 mice and F344/N rats. Mice and rats were exposed to 0, 0.5 or 1.0 p.p.m. ozone by inhalation for 24 or 30 months. There was an increased incidence of lung neoplasms in B6C3F1 mice. However, there was n...
Topics
- Adenocarcinoma, Bronchiolo-Alveolar
- Adenoma
- Animals
- Codon
- Dose-Response Relationship, Drug
- Evaluation Studies as Topic
- Female
- Genes, p53
- Genes, ras
- Immunohistochemistry
- Lung Neoplasms
- Mice
- Mice, Inbred Strains
- Mutation
- Ozone
- Sensitivity and Specificity
- Time Factors
- Tumor Suppressor Protein p53