Article
Angiotensin-I converting enzyme genotype DD is a risk factor for coronary artery disease.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Jun 1995
Beohar N, Damaraju S, Prather A, Yu Q T, Raizner A, Kleiman N S, Roberts R, Marian A J
Abstract excerpt
BACKGROUND: Coronary artery disease (CAD) is a polygenic disease whose phenotypic manifestation is due to interaction of a number of environmental factors with an underlying genetic background. A number of genes, including the angiotensin-I converting enzyme (ACE) gene, have been implicated in the pathogenesis of CAD. ACE can affect oxidation of LDL, endothelial cell function, and smooth muscle cell migration and...
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