Article
Angiotensin-I-converting enzyme DD genotype is a risk factor of coronary artery disease.
Scandinavian journal of clinical and laboratory investigation - 1 Apr 1997
Sigusch H H, Vogt S, Gruber U, Reinhardt D, Lang K, Surber R, Farker K, Müller S, Hoffmann A
Abstract excerpt
Coronary artery disease (CAD) is a polygenic disease whose phenotypic manifestation depends on the interaction of a number of environmental factors. A number of genes, including the angiotensin-I-converting enzyme (ACE) gene, have been implicated in the pathogenesis of CAD. ACE could affect smooth muscle cell and fibroblast migration and proliferation, low-density lipoprotein (LDL) oxidation and endothelial cell...
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