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Apoptosis and the Pathogenesis of Lymphoma

1 Jan 2000

Abstract excerpt

The pathogenesis of follicular lymphoma and chronic lymphocytic leukemia (CLL) involves the dysregulation of the bcl-2 protein. This protein is a critical regulator of apoptosis and interferes with the caspase cascade, which is the backbone of the apoptotic machinery. The multiple interactions of caspases with bcl-2 and its related proteins which comprise the bcl-2 family of proteins have become more clear over...

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PMID: 10859004
DOI: 10.1080/028418600430707

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