Article
Single nucleotide polymorphisms of the melanocortin-3 receptor gene are associated with substrate oxidation and first-phase insulin secretion in offspring of type 2 diabetic subjects.
The Journal of clinical endocrinology and metabolism - 1 Mar 2007
Rutanen Jarno, Pihlajamäki Jussi, Vänttinen Markku, Salmenniemi Urpu, Ruotsalainen Eija, Kuulasmaa Teemu, Kainulainen Sakari, Laakso Markku
Abstract excerpt
CONTEXT: The melanocortin-3 receptor (MC3R) is a part of the melanocortin system that regulates appetite and energy metabolism. The Thr/Thr 6 and Val/Val81 [corrected] polymorphisms of the MC3R gene have been previously associated with high insulin levels and obesity in children. OBJECTIVE: The objective was to determine whether single nucleotide polymorphisms (SNPs) of MC3R are associated with glucose, lipid,...
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