Article
Selection of a single amino acid substitution in the hemagglutinin molecule by chicken eggs can render influenza A virus (H3) candidate vaccine ineffective.
Journal of virology - 1 Aug 1995
Kodihalli S, Justewicz D M, Gubareva L V, Webster R G
Abstract excerpt
This study investigated whether a single amino acid change in the hemagglutinin (HA) molecule influenced the efficacy of formalin-inactivated influenza A (H3N1) vaccine candidates derived from high-growth reassortants between the standard donor of high-yield genes (A/PR/8/34 [H1N1]) and host cell...
Topics
- Animals
- Antibodies, Viral
- Antibody Specificity
- B-Lymphocytes
- Cell Line
- Chick Embryo
- Dogs
- Genotype
- Hemagglutinin Glycoproteins, Influenza Virus
- Hemagglutinins, Viral
- Humans
- Immunologic Memory
- Influenza A virus
- Influenza Vaccines
- Viral Envelope Proteins