Article
Cell lineage analysis of a mouse tumor.
Cancer research - 15 Jul 2008
Frumkin Dan, Wasserstrom Adam, Itzkovitz Shalev, Stern Tomer, Harmelin Alon, Eilam Raya, Rechavi Gideon, Shapiro Ehud
Abstract excerpt
Revealing the lineage relations among cancer cells can shed light on tumor growth patterns and metastasis formation, yet cell lineages have been difficult to come by in the absence of a suitable method. We previously developed a method for reconstructing cell lineage trees from genomic variability caused by somatic mutations. Here, we apply the method to cancer and reconstruct, for the first time, a lineage tree...
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