Article
Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2.
Genes & development - 15 Aug 1994
Yang J, Sato R, Goldstein J L, Brown M S
Abstract excerpt
Sterol-resistant CHO cells (SRD-1 cells) fail to repress sterol synthesis and LDL receptor gene transcription when incubated with 25-hydroxycholesterol. Here we trace the defect to a rearrangement in the gene encoding SREBP-2, a membrane-bound transcription factor that regulates cholesterol homeo...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- CCAAT-Enhancer-Binding Proteins
- CHO Cells
- Cloning, Molecular
- Cricetinae
- DNA, Complementary
- DNA-Binding Proteins
- Gene Rearrangement
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Recombinant Fusion Proteins
- Sterol Regulatory Element Binding Protein 1
- Sterol Regulatory Element Binding Protein 2
- Sterols